The analysis has several strengths and you can limitations

The prospective structure reduced the possibility of remember and you can solutions biases, and the higher level out-of storage faster prejudice due to an excellent losings to follow along with-right up. Diet plan try reviewed many times through the pursue-right up, and therefore got into account changes in eating practices and you can faster dimension error; yet not, specific mistake is actually inevitable. In the event strokes was in fact care about-claimed, study physicians, without knowing the latest worry about-claimed risk factor standing regarding members, examined participants’ medical info to ensure the fresh coronary attack analysis and categorize the brand new coronary attack particular. not, just like the twenty-four% of women that have coronary arrest about NHS I and thirty two% regarding the NHS II failed to bring permission to review its scientific information, we had been not able to classify the strokes once the ischemic otherwise hemorrhagic; for this reason, new numbers of coronary attack items were less. Nevertheless, the huge amount of participants as well as the long lifetime of pursue-right up offered sufficient ability to find clinically related variations in dangers away from complete stroke and you can heart attack items. On the other hand, new upgraded meta-analyses considering help for our conclusions towards weight reduction consumption off magnesium, potassium, and you may calcium and you will danger of complete coronary attack. A major maximum of the newest analysis was the shortcoming so you can separate the new independent outcomes of the three minerals with much certainty from the highest correlations among them. And additionally, due to the fact research population predominantly contains Caucasian females ( 12), the outcome of newest investigation might not be generalizable to help you males otherwise ethnically diverse communities.

To summarize, results from this type of dos large prospective education offer solid evidence so you can service an inverse association ranging from shared intakes regarding magnesium, potassium, and you will calcium supplements of dieting and coronary arrest chance. Brand new independent role each and every mineral throughout the reduced total of stroke risk is hard so you can establish. At the same time, the end result of them minerals towards the threat of coronary arrest separate from food sources is difficult to describe. This study supporting the advice of the Weight reduction Approaches to Stop Hypertension, Maximum Macronutrient Intake Trial to prevent Cardiovascular disease, and you will Mediterranean dieting, hence bring highest weight loss consumption of these nutrients.

The latest authors’ responsibilities was indeed below-SNA: performed statistical analyses and you will authored the fresh manuscript; DS, WCW, and you may KMR: offered critical viewpoints of one’s manuscript; and all experts: discover and you will recognized the final manuscript. None of your own article authors advertised a conflict of great interest linked to the research.


Backed by brand new NIH (gives UM1CA176726, UM1CA186107, D43TW009106, HL34594, CA87969, and you may HL088521) and Bernard Lown Heart disease Program (to help you SNA).


Information was obtained on potential confounding factors, including medical history, other aspects of dietary intake, and lifestyle behaviors that could be associated with intake of these minerals and risk of stroke. These variables were updated biennially and included cigarette smoking (never, past, or current), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks per week), menopausal status (premenopausal or postmenopausal), postmenopausal hormone therapy use (never, past, or current), parental history of early myocardial infarction (before age 60 y), multivitamin use (yes or no), thiazide use (yes or no), aspirin use at least 2 times/wk (yes or no), and history of hypertension, diabetes, or hypercholesterolemia (yes or no). Height and weight were self-reported at baseline, and weight was updated from follow-up questionnaire responses. BMI (in kg/m 2 ) was calculated as weight divided by height squared. BMI was divided into 3 categories (i.e., <25, 25 to <30, and ?30). Quintiles were calculated for total energy intake (kcal), and we used alcohol consumption categories of 0, 0 to <5, 5 to <10, 10 to <15, and ?15 g/d.

Age-standardized features out-of 86,149 women in brand new NHS I within the 1994 and you may 94,715 women in the latest NHS II into the 1995 by quintiles out of magnesium, potassium, and calcium supplements intakes 1

Pooled RRs (95% CIs) regarding complete, ischemic, and you may hemorrhagic strokes of the quintiles out of complete and weight reduction potassium intake inside the 86,149 feamales in this new NHS We and you will 94,715 feamales in brand new NHS II 1

By the apparently large amount of relationship ranging from such nutritional elements, i including looked at a combined magnesium, potassium, and you can calcium supplements diet plan get ( Desk 5). To have comparison of females regarding the high that have low quintiles regarding combined magnesium, potassium, and calcium supplements diet plan get, the newest pooled multivariate RR to have total stroke try 0.81 (95% CI: 0.72, 0.91; P-development = 0.003). Conclusions was comparable getting ischemic but not hemorrhagic coronary arrest.


The new relation anywhere between intakes off magnesium, potassium, and you will calcium supplements and you will threat of coronary arrest revealed in today’s research is much like this new family ranging from consumption of these nutrition and you can threat of IHD. In prospective degree, weight reduction consumption out-of magnesium and potassium was in fact inversely with the chance of IHD ( 46, 47), but there is zero family which have calcium intake and you may chance of IHD in females ( 48). And, consumption out of magnesium and you will calcium although not potassium was indeed of this all the way down likelihood of CVD death in a number of ( 24, 46, 49) yet not all of the ( 50) degree.